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Zika virus has biological similarities to other flaviviruses, such as West Nile virus, Japanese encephalitis virus (JEV) and dengue virus|ZIKV has an approximately 11 kb positive-stranded RNA genome, with untranslated regions flanking the 5' and 3' ends of its open reading frame|The genome is translated into structural proteins [capsid (C), precursor membrane (prM), and envelope (E)] and non-structural (NS) proteins (NS1, NS2A, NS2B, NS3, NS4A, NS4B, and NS5)|Precursor membrane (prM), one of the ZIKV structural proteins, plays an important role in the assembly of mature virions through cleavage of prM into M protein|Recent studies have suggested that prM protein might be implicated in the neurovirulence of ZIKV|Most vaccines targeting ZIKV include prM as the immunogen [PMID: 30116235]
Zika virus Premembrane; Zika virus PrM; ZIKV Premembrane; ZIKV PrM
100 µL
100 µL
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